Gaddafi, currently placed 13th in the league with 19 points from 23 matches, 1 point above the drop, are aiming to secure a win to improve their chances of avoiding relegation.
Meanwhile, Villa, holding the 5th spot with 42 points from 23 matches, are keen on maintaining their title aspirations and cannot afford to drop any more points.
Gaddafi have struggled greatly, failing to secure a victory in their last 9 league games and managing only 3 draws. Their latest match ended in a 1-all draw against UPDF in Bombo.
Villa, on the other hand, are looking to regain winning form after drawing their last three league matches, including a 1-1 draw at home against Bright Stars in their previous game.
In the reverse fixture, Villa emerged victorious with a 1-0 win against Gaddafi, with Ivan Bogere scoring the lone goal at the Muteesa II Stadium.
Examining their head-to-head record, Villa have won 3 out of their last 5 meetings with Gaddafi, drawn 1, and lost 1.
Gaddafi aim to secure victory to maintain their 13th position, creating a four-point gap from the relegation zone.
For Villa, a win is crucial to keep pace with league leaders Kitara. Kitara currently holds 47 points from 25 matches. Villa, presently 5 points behind, can narrow the gap to just 2 points with a victory while still holding the advantage of having a game in hand.