Napoli are nearing their second Scudetto in three seasons, sitting three points clear with four games left.
Coach Antonio Conte has overseen a remarkable turnaround. Their next match is against struggling Lecce.
Inter Milan, fresh from a 3-3 Champions League draw with Barcelona, face Verona, possibly without injured captain Lautaro Martinez.
A tight battle for the remaining Champions League spots sees six teams in contention.
Atalanta plays Monza, while Juventus travels to Bologna in a crucial clash. Roma, unbeaten in 18 league games, hosts Fiorentina.
Bologna’s Riccardo Orsolini, who recently scored against Inter, is a player to watch as they aim for a Champions League spot against his former club, Juventus.